tailieunhanh - High resolution melting curve analysis targeting the HBB gene mutational hotspot offers a reliable screening approach for all common as well as most of the rare beta-globin gene mutations in Bangladesh

Bangladesh lies in the global thalassemia belt, which has a defined mutational hot-spot in the betaglobin gene. The high carrier frequencies of beta-thalassemia trait and hemoglobin E-trait in Bangladesh necessitate a reliable DNA-based carrier screening approach that could supplement the use of hematological and electrophoretic indices to overcome the barriers of carrier screening. |

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