tailieunhanh - Comprehensive analysis of promoter-proximal RNA polymerase II pausing across mammalian cell types

For many genes, RNA polymerase II stably pauses before transitioning to productive elongation. Although polymerase II pausing has been shown to be a mechanism for regulating transcriptional activation, the extent to which it is involved in control of mammalian gene expression and its relationship to chromatin structure remain poorly understood. |

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