tailieunhanh - GATA3-dependent cellular reprogramming requires activation-domain dependent recruitment of a chromatin remodeler

Transcription factor-dependent cellular reprogramming is integral to normal development and is central to production of induced pluripotent stem cells. This process typically requires pioneer transcription factors (TFs) to induce de novo formation of enhancers at previously closed chromatin. Mechanistic information on this process is currently sparse. |

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