tailieunhanh - Characterisation of genetic regulatory effects for osteoporosis risk variants in human osteoclasts

Osteoporosis is a complex disease with a strong genetic contribution. A recently published genomewide association study (GWAS) for estimated bone mineral density (eBMD) identified 1103 independent genomewide significant association signals. Most of these variants are non-coding, suggesting that regulatory effects may drive many of the associations. |

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