tailieunhanh - High score of LDH plus dNLR predicts poor survival in patients with HER2- positive advanced breast cancer treated with trastuzumab emtansine

To investigate the prognostic value of derived neutrophil to lymphocyte ratio (dNLR) and lactate dehydrogenase (LDH) in patients with advanced HER2 positive breast cancer treated with trastuzumab emtansine. | Li et al. BMC Cancer 2022 22 29 https s12885-021-09131-6 RESEARCH Open Access High score of LDH plus dNLR predicts poor survival in patients with HER2- positive advanced breast cancer treated with trastuzumab emtansine Liru Li Lin Ai Lin Jia Lei Zhang Boya Lei and Qingyuan Zhang Abstract Objective To investigate the prognostic value of derived neutrophil to lymphocyte ratio dNLR and lactate dehydro- genase LDH in patients with advanced HER2 positive breast cancer treated with trastuzumab emtansine. Methods Fifty one patients with advanced HER2 positive breast cancer who received T-DM1 treatment in Harbin Medical University Cancer Hospital were selected. The clinical data and blood test indexes were collected and the ROC curve determined the optimal cut-off value. Kaplan-Meier survival curve and Cox regression model was used to analyze the effect of different levels of dNLR LDH LNI dNLR combined with LDH index before and after T-DM1 treat- ment on the survival of patients. Results The median PFS and OS of the patients with advanced HER2 positive breast cancer who received T-DM1 treatment were months and months respectively. The optimal cut-off value of LDH and dNLR before T-DM1 treatment was 244 U L P and P respectively. Higher LDH and dNLR were significantly cor- related with shorter median PFS and OS P 244 U L dNLR gt LNI gt 0 ECOG 1 and HER-2 IHC2 FISH before the T-DM1 treatment were the poor prognostic factors. LDH uptrend after the T-DM1 treatment also predicted poor prognosis. Conclusion Serum LDH gt 244 U L and dNLR gt before the T-DM1 treatment were prognostic risk factors for patients with advanced HER2 positive breast cancer receiving T-DM1 treatment. The higher LNI score was significantly associated with shorter PFS and OS. LDH uptrend after T-DM1 treatment was also related to the poor prognosis. Keywords dNLR LDH T-DM1 HER2 positive Prognosis Background Breast cancer is the most common cancer among

• Y khoa - Dược
• BMC Cancer
• HER2 positive
• Lactate dehydrogenase
• Lymphocyte ratio
• Trastuzumab emtansine
• Human epidermal growth factor receptor 2
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
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• Second cancer
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• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
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• Cancer hallmarks
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