tailieunhanh - A2M is a potential core gene in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a type of malignant tumor ranking the second in the incidence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been increasing in recent years. Small duct type of ICC has potential therapeutic targets. But overall, the prognosis of patients with ICC is usually very poor. | Zhang et al. BMC Cancer 2022 22 5 https s12885-021-09070-2 RESEARCH Open Access A2M is a potential core gene in intrahepatic cholangiocarcinoma Guanran Zhang1 Xuyue Liu1 Zhengyang Sun2 Xiaoning Feng1 Haiyan Wang3 Jing Hao1 and Xiaoli Zhang1 Abstract Background Intrahepatic cholangiocarcinoma ICC is a type of malignant tumor ranking the second in the inci- dence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been increasing in recent years. Small duct type of ICC has potential therapeutic targets. But overall the prognosis of patients with ICC is usually very poor. Methods To search latent therapeutic targets for ICC we programmatically selected the five most suitable microar- ray datasets. Then we made an analysis of these microarray datasets GSE26566 GSE31370 GSE32958 GSE45001 and GSE76311 collected from the Gene Expression Omnibus GEO database. The GEO2R tool was effective to find out differentially expressed genes DEGs between ICC and normal tissue. Gene Ontology GO function and Kyoto Encyclopedia of Genes and Genomes KEGG pathway enrichment analysis were executed using the Database for Annotation Visualization and Integrated Discovery DAVID v . The Search Tool for the Retrieval of Interacting Genes STRING database was used to analyze protein protein interaction of these DEGs and protein protein interaction of these DEGs was modified by . Survival analysis was performed using Gene Expression Profiling Interac- tive Analysis GEPIA online analysis tool. Results A total of 28 upregulated DEGs and 118 downregulated DEGs were screened out. Then twenty hub genes were selected according to the connectivity degree. The survival analysis results showed that A2M was closely related to the pathogenesis and prognosis of ICC and was a potential therapeutic target for ICC. Conclusions According to our study low A2M expression in ICC compared to normal bile duct tissue was an adverse .