tailieunhanh - A2M is a potential core gene in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is a type of malignant tumor ranking the second in the incidence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been increasing in recent years. Small duct type of ICC has potential therapeutic targets. But overall, the prognosis of patients with ICC is usually very poor. | Zhang et al. BMC Cancer 2022 22 5 https s12885-021-09070-2 RESEARCH Open Access A2M is a potential core gene in intrahepatic cholangiocarcinoma Guanran Zhang1 Xuyue Liu1 Zhengyang Sun2 Xiaoning Feng1 Haiyan Wang3 Jing Hao1 and Xiaoli Zhang1 Abstract Background Intrahepatic cholangiocarcinoma ICC is a type of malignant tumor ranking the second in the inci- dence of primary liver cancer following hepatocellular carcinoma. Both the morbidity and mortality have been increasing in recent years. Small duct type of ICC has potential therapeutic targets. But overall the prognosis of patients with ICC is usually very poor. Methods To search latent therapeutic targets for ICC we programmatically selected the five most suitable microar- ray datasets. Then we made an analysis of these microarray datasets GSE26566 GSE31370 GSE32958 GSE45001 and GSE76311 collected from the Gene Expression Omnibus GEO database. The GEO2R tool was effective to find out differentially expressed genes DEGs between ICC and normal tissue. Gene Ontology GO function and Kyoto Encyclopedia of Genes and Genomes KEGG pathway enrichment analysis were executed using the Database for Annotation Visualization and Integrated Discovery DAVID v . The Search Tool for the Retrieval of Interacting Genes STRING database was used to analyze protein protein interaction of these DEGs and protein protein interaction of these DEGs was modified by . Survival analysis was performed using Gene Expression Profiling Interac- tive Analysis GEPIA online analysis tool. Results A total of 28 upregulated DEGs and 118 downregulated DEGs were screened out. Then twenty hub genes were selected according to the connectivity degree. The survival analysis results showed that A2M was closely related to the pathogenesis and prognosis of ICC and was a potential therapeutic target for ICC. Conclusions According to our study low A2M expression in ICC compared to normal bile duct tissue was an adverse .

• Y khoa - Dược
• BMC Cancer
• Intrahepatic cholangiocarcinoma
• Hub genes
• Gene expression profiling
• Malignant tumor
• Potential therapeutic
• Cancer patient pathways
• Colorectal cancer
• Lung cancer
• Breast cancer
• Prostate cancer
• Ovarian cancer
• Cancer detection
• Ovarian cancer symptoms
• Ovarian cancer signs
• Ovarian cancer tests
• Cancer biomarkers
• Pediatric cancer
• Familial cancer predisposition
• Hereditary cancer syndrome
• Genetic cancer susceptibility
• Advanced cancer
• Biliary tract cancer
• Multimodal intervention
• Pancreatic cancer
• Physical activity
• Breast cancer screening
• Familial breast cancer
• Young breast cancer survivors
• High risk relatives
• Randomized trial
• Childhood cancer
• Childhood cancer survivor
• Thyroid cancer screening
• Secondary cancer
• Cancer screening
• Community awareness
• Cancer education
• Cervical cancer
• Prior cancer
• Cancer survivors
• Cancer registry
• Second cancer
• Surgical oncology
• Cancer imaging
• Radiation oncologists
• Medical oncologists
• Oesophagogastric cancer
• Liver cancer
• Hepatobiliary cancer
• Multidisciplinary rehabilitation
• EGFR mutation
• Family history of cancer
• Inherited susceptibility
• Cancer predisposition genes
• Lung cancer aetiology
• Cancer stem cells
• Oct4 overexpressing lung cancer
• Human lung cancer xenograft model
• Disease free survivals
• Cancer hallmarks
• Cancer genesis
• Defiant disease
• Mutational signature
• Cancer diagnosis
• Cancer genomics
• Molecular medicine
• Whole genome sequencing
• Cancer susceptibility gene
• Breast cancer prognosis
• Next generation sequencing
• Quality of care
• Quality indicators
• Shifting cancer care
• German cancer society
• Colorectal cancer screening
• Stomach cancer screening
• Lung cancer survivor
• Physician recommendation
• Total number of lymph nodes
• Lymph node ratio
• Left colon cancer
• Right colon cancer
• Overall survival
• Cumulative incidence
• Esophageal cancer
• Head and neck cancer
• Metachronous cancer
• Young onset
• Reproductive cancer
• Risk factor
• Early detection of cancer
• Gastric cancer incidence
• Population based specialized registry
• Gastric cancer survival
• Gastric cancer clinical characteristics
• Gastric cancer pathological characteristics
• Lung Cancer Screening
• Racial disparities
• Lung Cancer diagnosis
• Screening adherence
• Second primary colorectal cancer
• Standardized incidence ratio
• Left sided colon cancer
• Right sided colon cancer
• Quality of cancer care
• Population based study