tailieunhanh - Clinical significance of mucinous component in colorectal adenocarcinoma: A propensity score-matched study

This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods: Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed. | Yan et al. BMC Cancer 2021 21 1286 https s12885-021-09031-9 RESEARCH Open Access Clinical significance of mucinous component in colorectal adenocarcinoma a propensity score-matched study Chuanwang Yan1 Hui Yang2 Lili Chen3 Ran Liu2 Wei Shang2 Wenguang Yuan2 Fei Yang3 Qing Sun4 and Lijian Xia3 Abstract Background This study aims to investigate the clinical significance and prognostic value of mucinous component MC in colorectal adenocarcinoma AC . Methods Patients with colorectal AC and AC with MC ACMC 1 100 underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed. Propensity score matching PSM was performed according to a 1 1 ratio. Receiver-operating characteristic ROC curve was used to identify the optimal cut-off value of MC ratio for prognostic prediction. The clinicopathological features and 3-year overall survival OS of AC patients mucinous adenocarcinoma MAC MC gt 50 patients and ACMC 1 50 patients were compared before and after matching. Multivariable analysis was used for analyzing independent risk factors related to prognosis. Results A total of 532 patients were enrolled in this study. Patients with AC MAC and ACMC 1 50 exhibited dif- ferent clinicopathological features. However their 3-year OS rates were similar vs. vs. P . After matching ROC curve determined 70 as the optimal cut-off value. And patients with ACMC gt 70 had a much poorer 3-year OS compared with ACMC 1 70 patients and AC patients vs. vs. P 70 was revealed as a risk factor for poor survival in univariate analysis HR 95 CI P though not an independent risk factor in multivariable analysis HR 95 CI P . Conclusions MAC is usually diagnosed at an advanced stage. MAC has a similar survival with AC and ACMC 1 50 patients before and after matching. Patients with ACMC gt 70 exhibited a much poorer OS and should be given more clinical attention. Keywords