tailieunhanh - Synergistic efficacy of inhibiting MYCN and mTOR signaling against neuroblastoma

Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in NB and various other cancers that promote MYCN stabilization. |

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