tailieunhanh - Crosstalk between autophagy and DNA repair systems

Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity. Hence, in collaboration with DNA damage repair and response mechanisms, autophagy contributes to the maintenance of genomic stability and integrity. Yet, connections and interactions between these two systems are not fully understood. In this review article, current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed. | Turkish Journal of Biology Turk J Biol 2021 45 235-252 http biology TÜBİTAK Review Article doi biy-2103-51 Crosstalk between autophagy and DNA repair systems 1 1 1 2 3 3 Sinem DEMİRBAĞ-SARIKAYA Hatice ÇAKIR Devrim GÖZÜAÇIK Yunus AKKOÇ 1 SUNUM Nanotechnology Research and Application Center İstanbul Turkey 2 Koç University School of Medicine İstanbul Turkey 3 Koç University Research Center for Translational Medicine KUTTAM İstanbul Turkey Received Accepted Published Online Final Version Abstract Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging neurodegenerative diseases and cancer. Intrinsic or extrinsic stress stimuli . reactive oxygen species or ionizing radiation cause DNA damage. As a biological stress response autophagy is activated following insults that threaten DNA integrity. Hence in collaboration with DNA damage repair and response mechanisms autophagy contributes to the maintenance of genomic stability and integrity. Yet connections and interactions between these two systems are not fully understood. In this review article current status of the associations and crosstalk between autophagy and DNA repair systems is documented and discussed. Key words Autophagy DNA damage DDR DNA repair 1. Introduction cause loss of genetic information and even trigger genomic Maintenance of cellular homeostasis in living organisms instability and rearrangements. Fortunately in healthy requires a balance between anabolic and catabolic individuals most of these lesions are repaired by the reactions. Various endogenous and exogenous insults lead activation of DNA damage response DDR and following to the activation of cellular and organismal stress response DNA damage repair mechanisms. Although autophagic mechanisms. Macroautophagy autophagy herein is one machinery

• Sinh học
• Journal of Biology
• DNA damage
• DNA repair
• Biological mechanisms
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• Mechanistic toxicology
• Cell biology
• Autophagy deficient cells
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