tailieunhanh - Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease

Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of the HIV2 protease (PR2) in bound and unbound forms exhibit structural asymmetry that is important for ligand recognition and binding. |

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