tailieunhanh - Summary of Chemisttry doctoral thesis: Synthesis and evaluation of anti-cancer Synthesis and evaluation of anti-cancer

Synthesis and structural determination of some 4-aminoquinazoline derivatives containing prop-2-yn-1-yloxy substituents at C-6 position; research and synthesize and determine the hybrid compound structure containing Quinazoline frame; research on carcinogenic activity and inhibition of acetylcholinesterase enzyme of synthetic compounds; studying protein docking and predicting the pharmacokinetic properties of some compounds that inhibit the enzyme acetylcholinesterase. | MINISTRY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY SCIENCE AND TECHNOLOGY ------------------ NGA NGUYEN THI SYNTHESIS AND EVALUATION OF ANTI CANCER AND ANTI ALZHEIMER ACTIVITY OF HYBRID STRUCSTURE CONTAINING 4-AMINOQUINAZOLINE FRAME Major Organic chemistry Code SUMMARY OF CHEMISTTRY DOCTORAL THESIS Hanoi-2020 The work was completed at the Vietnam academy of Science and Technology Supervisors Supervisor 1 . Trung Vu Quoc Supervisor 2 Doc. Giang Le Nhat Thuy Reviewer 1 Reviewer 2 Reviewer 3 The thesis will be defended before the Doctoral Dissertation Council at the Academy of Science and Technology - Vietnam Academy of Science and Technology. No. 18 - Hoang Quoc Viet Cau Giay Hanoi. At . time . . day . month . year 201 . 2 A. INTRODUCTION 1. The urgency scientific and practical significance of the thesis Many typical Quinazoline compounds have been introduced into the production of cancer treatment targets by inhibiting the enzyme Tyrosine Kinases such as gefitinib Iressa erlotinib Tarceva lapatinb Tykerb and vandetanib Caprelsa . The current problem is that the effectiveness of cancer treatment is limited to a small group of patients due to the heterogeneity of molecules inside the tumor and between tumors the ability to respond to drugs poor and resistant drugs due to receptor mutations. The combination therapy of two or more drugs or the use of a combination of two or more active ingredients with different mechanisms of action but having the same purpose of action is a promising research direction. Therefore the study designed and synthesized new Quinazoline compounds with the goal of inhibiting Tyrosine Kinases and hybridizing these molecules with components that inhibit cancer cells under other mechanisms such as AZT or triazole to Incorporating the unique pharmacological properties of each component into a single hybrid molecule towards the goal of multifunctional inhibition will be a very .