tailieunhanh - Dissertation summary Organic chemistry: Synthesis and antiinflammatory, antiproliferative activities of new Coxib–Combretastatin hybrids

Objectives of the dissertation: Structured design of coxib - combretastatin hybrid compounds; synthesize coxib - combretastatin hybrid compounds; screening for anti-cancer and anti-inflammatory activities of hybrid compounds; icreening for anti-cancer and anti-inflammatory activities of hybrid compounds. | MINISTERY OF EDUCATION VIETNAM ACADEMY OF AND TRAINING SCIENCE AND TECHNOLOGY GRADUATE UNIVERSITY OF SCIENCE AND TECHNOLOGY ------------- NGUYEN THI THUY HANG SYNTHESIS AND ANTIINFLAMMATORY ANTIPROLIFERATIVE ACTIVITIES OF NEW COXIB COMBRETASTATIN HYBRIDS Scientific Field Organic Chemistry Classification Code DISSERTATION SUMMARY HA NOI - 2021 The dissertation was completed at Institute of Chemistry Vietnam Academy of Science and Technology Scientific Supervisors 1. Assoc. Prof. Dr. Ngo Quoc Anh 2. Assoc. Prof. Dr. Vu Dinh Hoang 1st Reviewer . . 2nd Reviewer . . 3rd Reviewer . . The dissertation will be defended at Graduate University of Science And Technology Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Cau Giay District Ha Noi City. At . hour . date . month .2021. The dissertation can be found in National Library of Vietnam and the library of Graduate University of Science And Technology Vietnam Academy of Science and Technology. 1 INSTRODUCTION 1. The urgency of the thesis Cancer is a group of diseases that involve disorganized cell division and cells that have the ability to invade other tissues by either growing directly into nearby tissue or moving to multiple locations different metastatic . According to the Global Cancer Organization GLOBOCAN 2018 there are currently more than 300 000 people living with cancer nationwide there are 164 671 new cases 114 871 people die from this disease. Globally there are about 23 million people infected of which more than 14 million people are newly infected and 8 million 2 hundred thousand people die. The World Health Organization WHO ranked Vietnam in the top 50 countries in the top 2 of the cancer map. Researching to find cancer treatment drugs with few side effects is one of the directions that is always interested in the scientific community. Among current treatments chemotherapy is a cancer treatment that uses one or more anticancer drugs - cytotoxic. One of the anti-cancer drugs used today

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