tailieunhanh - Optimization of yield in the synthesis of 2-chloroquinoline-3-carbaldehyde by box-hunter designed experiments via the vilsmeier-haack reaction

2-chloroquinoline-3-carbaldehyde (QCl) is one of key organic compounds for synthesizing numerous products which possess biological potential. According to Vilsmeier - Haack, QCl was prepared by refluxing a mixture of acetanilide (A) and phosphoryl chloride (P) in N,N-dimethylformamide (D). |

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