tailieunhanh - Leveraging protein quaternary structure to identify oncogenic driver mutations

Identifying key “driver” mutations which are responsible for tumorigenesis is critical in the development of new oncology drugs. Due to multiple pharmacological successes in treating cancers that are caused by such driver mutations, a large body of methods have been developed to differentiate these mutations from the benign “passenger” mutations which occur in the tumor but do not further progress the disease. |

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