tailieunhanh - Structural prediction of the interaction of the tumor suppressor p27KIP1 with cyclin A/ CDK2 identifies a novel catalytically relevant determinant

The cyclin-dependent kinase 2 (CDK2) together with its cyclin E and A partners is a central regulator of cell growth and division. Deregulation of CDK2 activity is associated with diseases such as cancer. The analysis of substrates identified S/T-P-X-R/K/H as the CDK2 consensus sequence. |