tailieunhanh - Measuring ofloxacin in pharmaceuticals using the differential pulse voltammetric method

The differential pulse voltammetric method at a hanging mercury drop electrode was used to determine the presence of ofloxacin. In this study, the conditions under which differential pulse voltammetric measurement could be conducted were examined and established. | JOURNAL OF SCIENCE OF HNUE Chemical and Biological Sci. 2013 Vol. 58 No. 9 pp. 77-84 This paper is available online at http MEASURING OFLOXACIN IN PHARMACEUTICALS USING THE DIFFERENTIAL PULSE VOLTAMMETRIC METHOD Tran Quang Hai1 Duong Quang Phung2 Vu Thi Huong2 and Tu Vong Nghi3 1 Faculty of Chemical Technology Hanoi University of Industry 2 Faculty of Chemistry Hanoi National University of Education 3 Faculty of Chemistry Hanoi University of Science Vietnam National University Hanoi Abstract. The differential pulse voltammetric method at a hanging mercury drop electrode was used to determine the presence of ofloxacin. In this study the conditions under which differential pulse voltammetric measurement could be conducted were examined and established. The proposed method exhibited a sensitive response to ofloxacin in the range from to µg mL with a detection limit of µg mL. The differential pulse voltammetric method was applied to measure ofloxacin in pharmaceuticals with high degree of precision and accuracy. Keywords Ofloxacin pulse voltammetric method voltammetry. 1. Introduction Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone 8 which has been widely used to inhibit the DNA gyrase of most Gram-negative bacteria many Gram-positive bacteria and some anaerobes. It is popular because it is rapidly absorbed it s a potent inhibitor and it is inexpensive 7 . In Vietnam ofloxacin is produced by a number of medical companies. The use of ofloxacin at a suitable dosage can prevent viruses from attaching but an overdose is harmful. Therefore determining of amount of ofloxacin that is present in a medicine is necessary to control the amount of ofloxacin that is taken into the body. Over the years spectrophotometry 5 High Performance Liquid Chromatography HPLC 2 molecularly imprinted solid-phase extraction - Liquid Chromatography Received August 10 2013. .