tailieunhanh - Nghiên cứu bào chế hệ tự nano nhũ hóa rosuvastatin rắn

Mục tiêu của bài viết là hóa rắn hệ nano tự nhũ hóa rosuvastatin (SNEDDS Ros) để ứng dụng vào dạng thuốc rắn. Hệ SNEDDS Ros lỏng được hóa rắn bằng phương pháp tạo hạt và phương pháp phun sấy. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 3 2020 1-9 Original Article Development of Solid Self Nanoemulsified Drug Delivery System Containing Rosuvastatin Tran Thi Hai Yen1 Nguyen Thi Yen1 Nguyen Canh Hung1 Phan Thi Nghia1 2 Pham Bao Tung1 Nguyen Dang Hoa1 Vu Thi Thu Giang1 1 Hanoi University of Pharmacy 13-15 Le Thanh Tong Hoan Kiem Hanoi Vietnam 2 National Institute of Drug Quality Control 48 Hai Ba Trung Hoan Kiem Hanoi Vietnam Received 03 June 2020 Revised 14 July 2020 Accepted 29 July 2020 Abstract This study aims to solidify the self-nanoemulsifying drug delivery system with rosuvastatin SNEDDS Ros for application in solid dosage forms. The liquid SNEDDS Ros system is solidified by granulation and spray drying methods. Solid SNEDDS Ros was evaluated on the drug content the Carr index nanoemulsification efficiency and several criteria of nanoemulsion formed after emulsification of solid SNEDDS Ros such as droplet size polydispersion index PDI the drug proportion in the oil phase. The study results show that solid SNEDDS Ros prepared by granulation method using Prosolv SMCC 90 as an adsorbent had good flowability with the Carr index of about 15. The nanoemulsion obtained after emulsification of the solid SNEDDS had an average particle size of 15 nm PDI less than drug nanoemulsified efficiency of 94 and drug proportion in the oil phase of 84 . Keywords Rosuvastatin SNEDDS Solid SNEDDS solidification. ________ Corresponding author. E-mail address giangvtt@ https 2588-1132 1 2 . Yen et al. VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 3 2020 1-9 Nghiên cứu bào chế hệ tự nano nhũ hóa rosuvastatin rắn Trần Thị Hải Yến1 Nguyễn Thị Yến1 Nguyễn Cảnh Hưng1 Phạm Bảo Tùng1 Phan Thị Nghĩa1 2 Nguyễn Đăng Hòa1 Vũ Thị Thu Giang1 Trường Đại học Dược Hà Nội 13-15 Lê Thánh Tông Hoàn Kiếm Hà Nội Việt Nam 1 2 Viện Kiểm nghiệm thuốc Trung ương 48 Hai Bà Trưng Hoàn Kiếm Hà Nội .