tailieunhanh - Tác dụng của cao chiết methanol cây Môn nước (Colocasia esculenta (L.) Schott) với mô hình gây tổn thương gan bằng Paracatamol ở chuột

Bài viết trình bày các kết quả nghiên cứu về tác dụng tăng cường và bảo vệ chức năng gan trên mô hình gây tổn thương gan chuột Swiss albino bằng paracetamol của cao chiết methanol cây Môn nước. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 3 2020 66-75 Original Article Hepatoprotective Activities of Colocasia esculenta L. Schottin Mice Model with Liver Injury Induced by Paracetamol Nguyen Quang Huy1 Le Quy Thuong1 2 Hoang Xuan Huy3 Tran Quoc Hung3 Phi Thi Mai Huong3 Tran Quoc Viet3 Le Thi Phuong Hoa4 1 Faculty of Biology VNU University of Science 334 Nguyen Trai Thanh Xuan Hanoi Vietnam 2 Phu Tho Obstetrics amp pediatrics center Nong Trang Viet Tri Phu Tho Vietnam 3 Phu Tho College of Medicine and Pharmacy Gia Cam Viet Tri Phu Tho Vietnam 4 Faculty of Biology Hanoi National University of Education 136 Xuan Thuy Cau Giay Hanoi Vietnam Received 24 May 2020 Revised 26 June 2020 Accepted 29 June 2020 Abstract This paper uses the model of experimental mouse liver damage with paracetamol to evaluate the liver protective effects of the methanol extract Colocasia esculenta L. Schott MCE . After 8 days the hepatoprotective activities of MCE in mice damaged by paracetamol at doses of 500 1 000 and 2 000 mg kg day proved effective as the AST enzyme content decreased by and respectively and ALT decreased by and respectively. MCE at a dose of 1 000 mg kg day had a protective effect equivalent to that of silymarin used in liver treatment at a dose of 50 mg kg day and MCE at a dose of 2 000 mg kg day had better effect. Observation of the microscopic liver tissue cross section also revealed that the mice treated with MCE of C. esculenta at doses of 1 000 and 2 000 mg kg day showed significantly improvement in their liver tissues compared to the non-treated control group. Keywords Colocasia esculenta hepatoprotective paracetamol. ________ Corresponding author. E-mail address huynq@ https 2588-1132 66 . Huy et al. VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 36 No. 3 2020 66-75 67 Tác dụng của cao chiết methanol cây Môn nước Colocasia esculenta L. .