tailieunhanh - Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: Analysis of the desminib series by competitive allele specific Taqman PCR technology

Aggressive fibromatosis (AF) is a rare fibroblastic proliferative disease with a locally aggressive behavior and no distant metastasis, characterized by driver mutations in CTNNB1 or the APC gene. When progressive and/or symptomatic AF is not amenable to local management, a variety of medical treatments may be efficient, including imatinib mesylate. |

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