tailieunhanh - Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms

The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer response to anthracyclines and of long-term safety. |

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