tailieunhanh - Tỷ lệ hội chứng Cushing và khảo sát nồng độ Cortisol máu trên bệnh nhân hội chứng thận hư kháng Corticosteroid

Hội chứng thận hư (HCTH) kháng corticoid khiến trẻ phải nhập viện nội trú nhiều lần tại Bệnh viện Nhi Trung ương. Phác đồ điều trị là corticoid liều cao, kéo dài kết hợp với thuốc ức chế miễn dịch, khiến trẻ có nguy cơ cao mắc hội chứng Cushing do thuốc cùng nhiều biến chứng bệnh khác. | Journal of Pediatric Research and Practice Vol. 4 No. 3 2020 1-7 Research Paper Prevalence of Cushing s Syndrome and Investigate Plasma Cortisol Levels in Children with Steroid Resistant Nephritic Syndrome Duong Thi Thanh Binh1 Nguyen Thu Huong1 Truong Manh Tu1 Nguyen Thi Linh2 Nguyen Phu Dat3 1 Vietnam National Children s Hospital 18 879 La Thanh Dong Da Hanoi Vietnam 2 Bac Ninh Obstetrics and Pediatrics Hospital Huyen Trang Dai Phuc Bac Ninh Vietnam 3 Hanoi Medical Univercity Ton That Tung Kim Lien Dong Da Hanoi Vietnam Received 30 December 2019 Revised 10 June 2020 Accepted 29 June 2020 Abstract Purpose To determine the prevalence of Cushing s syndrome and investigate plasma cortisol levels in children with SRNS. Methods A crossesional study was children with SRNS at Vietnam National Children s Hospital from June 2018 to July 2019 were enrolled in the study. Results The prevalence of Cushing syndrome in children with SRNS was mainly in boys 78 and the childrens from 2 to 10 years old . Duration of using corticoid below 5 years had the prevalance of Cushing syndrome was . Low plasma cortisol levels in children with Cushing syndrome accounted for markedly low when children with changes in body shape as round face 100 weight gain cetral fat and hirsutism . Conclusions Children with SRNS had a high rate of Cushing s syndrome mainly in boys and ages from 2 to 10 years old. Plasma cortisol levels decreased clearly in 2 children with Cushing s syndrome with changes in body shape or round face weight gain central fat hirsutism. Keywords Cushing syndrome Steroid resistant nephrotic syndrome SRNS . Corresponding author. E-mail address ybinh6283@ https 1 2 . Binh et al. Journal of Pediatric Research and Practice Vol. 4 No. 3 2020 1-7 Tỷ lệ hội chứng Cushing và khảo sát nồng độ Cortisol máu trên bệnh nhân hội chứng thận hư kháng Corticosteroid Dương Thị Thanh Bình1 Nguyễn Thu