tailieunhanh - CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMTlike process

Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (CYR61/CCN1) expression level is correlated to osteosarcoma aggressiveness in preclinical model and in patient tumor samples. | CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMTlike process

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