tailieunhanh - Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

Targeting the type 1 insulin-like growth factor receptor (IGF1R) in breast cancer remains an ongoing clinical challenge. Oncogenic IGF1R-signaling occurs via activation of PI3K/AKT/MAPK downstream mediators which regulate cell proliferation and protein synthesis. | Insulin-like growth factor receptor and sphingosine kinase are prognostic and therapeutic targets in breast cancer

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