tailieunhanh - RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome condensation 2 (RCC2), which binds the switch regions of Rac1 to prevent access from GEFs. | RCC2 over-expression in tumor cells alters apoptosis and drug sensitivity by regulating Rac1 activation

TÀI LIỆU LIÊN QUAN
TỪ KHÓA LIÊN QUAN