tailieunhanh - Summary of new aspect of the thesis: Nghiên cứu độc tính và tác dụng hạ glucose máu của viên Andiabet trên thực nghiệm

Several new models have been implemented: evaluate the effect inhbitivity on hyperglycemic postprandial blood glucose of reagent in glucose/sucrose/starch tolerance test in normal and diabetic mice and the effect antagonism with insulin resistance in type 2 diabetic mice (the technique of "Hyperinsulinemic - euglycemic clamp test") | Summary of new aspect of the thesis Nghiên cứu độc tính và tác dụng hạ glucose máu của viên Andiabet trên thực nghiệm 1 INTRODUCTION Type 2 diabetes mellitus T2D is a metabolic disorder with complex mechanisms and pathophysiological abnormalities. It is extremely hard to reverse T2D disease state with monotherapy. Thus combination therapy is becoming a promising alternative choice in clinical practice by designing drug combinations or compound drugs to interact with multiple targets and achive synergitic treatment effect. For example traditional Vietnamese medicines are attracting more attentions for their efficacy and less frequent side effects for treating T2D. Lagerstroemia speciosa L. Pers Gynostemma pentaphyllum Thunb. Makino Anemarrhenae Aspheloides Bunge has been reported to alleviate hyperglycemia and hyperlipemia in many preclinical and clinical studies and have been combined into the soft form of Vinabetes. However Vinabetes has only been extracted in laboratory and there are no adequate pharmacological studies. Andiabet is a compound of 3 Vietnamese herbal medicines composition above. The aim of this study was to investigate the toxicity and the hypoglycemic effect of Andiabet in experimental animals with the following objectives 1. Determine of acute toxicity and longterm toxicity by Andiabet. 2. Evaluate the hypoglycemic effect and several hypoglycemic mechanisms of Andiabet tablets in experiment. Chapter 1. OVERVIEW . OVERVIEW ABOUT THE DIABETES MELLITUS . Definition classification diagnostic criteria for diabetes and pathogenetic mechanism of diabetes type 2 . Definition Diabetes is a metabolic disorder characterized by hyperglycemia the result of a deficiency of insulin secretion impaired functioning of insulin or both. Chronic hyperglycemia is often 2 associated with damage disorders and impaired function of many organs especially the eyes kidneys nerves heart and blood vessels. . Classification Diabetes is divided into 4 .