tailieunhanh - Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and is a positive predictive marker of immunotherapy, it is routine practice to evaluate the MSI status of resected tumors in CRC patients. | Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

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