tailieunhanh - Development of a practical synthesis of etravirine via a microwave-promoted amination

Etravirine (ETV) was approved as the second generation drug for use in individuals infected with HIV-1 in 2008 by the . FDA with its unique antiviral activity, high specificity, and low toxicity. However, there are some shortcomings of the existing synthetic routes, such as the long reaction time and poor yield. | Development of a practical synthesis of etravirine via a microwave-promoted amination