tailieunhanh - Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl/aryl- 4, 10 dihydrobenzo [4, 5] imidazo [1, 2-a] pyrimidin-4-one derivatives

A series of novel 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2- a]pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido[1,2- a]benzimidazol-4(10H)-ones and screened for for their in vitro anti-tuberculosis activities against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. | Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl aryl- 4 10 dihydrobenzo 4 5 imidazo 1 2-a pyrimidin-4-one derivatives Current Chemistry Letters 9 2020 1 8 Contents lists available at GrowingScience Current Chemistry Letters homepage Synthesis and anti-tuberculosis studies of 10-phenyl sulfonyl-2-alkyl aryl- 4 10 dihydrobenzo 4 5 imidazo 1 2-a pyrimidin-4-one derivatives K. V. Jagannatha b a Department of Studies in Chemistry Central College Campus Dr. B. R. Ambedkar Veedhi Bangalore University Bengaluru-560001 India b Department of Chemistry School of Applied Sciences REVA University Bengaluru-560064 India CHRONICLE ABSTRACT Article history A series of novel 10-phenylsulfonyl-2-substituted-4 10 dihydrobenzo 4 5 imidazo 1 2- Received March 11 2019 a pyrimidin-4-one derivatives obtained from N-sulfonation of 2-substituted-pyrimido 1 2- Received in revised form a benzimidazol-4 10H -ones and screened for for their in vitro anti-tuberculosis activities April 11 2019 against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay MABA Accepted June 12 2019 method. The structures were established on the basis of their IR 1H-NMR 13C-NMR ESI-MS Available online data and also the compound with 3f were crystallized and analysed by single crystal X-ray June 12 2019 diffraction studies. Keywords Pyrimido 1 2-a benzimidazolone Sulfonamide Anti-tuberculosis Single crystal x-ray diffraction Ionic liquid 2020 by the authors licensee Growing Science Canada. 1. Introduction Tuberculosis TB is a dangerous disease caused by species found in Mycobacterium tuberculosis complex that includes M. tuberculosis Mtb . In the year 2012 an estimated million people developed TB and million died from the disease1 including 320 000 deaths among HIV-positive people . The number of TB deaths is unacceptably large given that most are preventable. Nearly 20 years after the WHO declaration of TB as a global public health emergency. So the