tailieunhanh - Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides

Obtained by the interaction of 2-amino-3,3-dichloroacrylonitrile and chlorosulphonyl isocyanate (Z)-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)sulfamoyl chloride reacts easily with excess of the aliphatic amine to form new (Z)-N-(5-(dichloromethylene)-2-oxoimidazolidin-4-ylidene)-N'-substituted sulfonamides. | Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides Current Chemistry Letters 8 2019 199 210 Contents lists available at GrowingScience Current Chemistry Letters homepage Synthesis and anticancer activity of new substituted imidazolidinone sulfonamides Oleh V. Shablykina Yurii Eu. Korniia Victoriya V. Dyakonenkob Olga V. Shablykinaa c and Volodymyr S. Brovaretsa a Department of Chemistry of Bioactive Nitrogen-Containing Heterocyclic Bases . Kukhar Institute of Bioorganic Chemistry and Petrochemistry NAS of Ukraine Murmanska st. 1 Kyiv 02094 Ukraine b SSI Institute for Single Crystals National Academy of Sciences of Ukraine Kharkiv Ukraine c Department of Chemistry Taras Shevchenko National University of Kyiv Kyiv Ukraine CHRONICLE ABSTRACT Article history Obtained by the interaction of 2-amino-3 3-dichloroacrylonitrile and chlorosulphonyl Received March 17 2019 isocyanate Z - 5- dichloromethylene -2-oxoimidazolidin-4-ylidene sulfamoyl chloride Received in revised form reacts easily with excess of the aliphatic amine to form new Z -N- 5- dichloromethylene -2- May 20 2019 oxoimidazolidin-4-ylidene -N -substituted sulfonamides. According to the National Cancer Accepted May 28 2019 Institute USA examinations two of the six synthesized sulfonamides showed a high Available online anticancer activity. May 30 2019 Keywords Z -N- 5- Dichloromethylene -2- oxoimidazolidin-4-ylidene -N - substituted sulphonamides Heterocyclization Anticancer Activity 2019 by the authors licensee Growing Science Canada. 1. Introduction Sulfonamides are one of the oldest group of synthetic drugs. Investigations of the antibiotic properties of Prontosil streptocide made it possible to find of its activity source metabolite Sulfanilamide Fig. 1 which formed in organism through This discovery initiated the era of drugs directed synthesis and the study of the structure-activity relationship. Later it was shown that the list of .

• Hoá học
• Synthesis and anticancer
• Substituted imidazolidinone sulfonamides
• National Cancer Institute
• Six synthesized sulfonamides
• Structure activity relationship
• BMC Chemistry
• 6 isomer
• Ring closing
• Ring opening strategy
• Bulky substituent
• Semi synthesis
• Anticancer scaffold
• Facile synthesis
• Anticancer activities
• β naphthyl carbamate
• Thiazole derivatives
• Luận án Tiến sĩ
• Luận án Tiến sĩ Hóa học
• Organic chemistry
• Tubulysin derivatives
• Anticancer activity
• Synthesis and evaluation
• Summary of Organic Chemistry doctoral thesis
• Organic Chemistry doctoral thesis
• Biological synthesis
• Silver nanoparticles
• Electron microscopy
• PC3 human prostate cancer cell lines
• Thiourea derivatives
• Exhibited biological activities
• Benzenesulfonamide derivatives
• Biological activity
• Coupling reaction
• Hydrazonoyl halides
• Molecular docking
• Hydrazonoyl chlorides
• Phenylhydrazinecarbo thioamide
• Fluorinated thiourea
• Antimicrobial and anticancer activity
• Biological activities
• Employed standard antitumor drug
• Multi component reactions
• Benzoxazole molecules
• Antimicrobial activity
• Native silver resistant
• Subsequent antibacterial
• Journal of Chemistry
• 7 Ethyl 10 hydroxycamptothecin
• Hepatocellular carcinoma
• Anticancer drug irinotecan
• Anticancer agent against HCC
• Hepatocellular carcinoma (HCC)
• Dicyanidoargentate (I)
• Dicyanidoaurate (I)
• Coordination polymers
• X ray single crystal analyses
• Thiophene derivatives
• Anti microbial
• Substituted benzylideneamino
• Reactive oxygen species
• Novel quinazolinone‑based rhodanines
• Pharmacological activities
• Isopropyl eugenoxyacetate
• Pt(II) complexes
• Pyridine derivatives
• Natural sciences
• Chiral azomethine ligand
• Photophysical properties
• In vitro cytotoxicity
• Cancer cell lines
• One dose assay
• Anticancer agents
• Human cancer cell lines
• 5 Acetylimidazole
• Multicomponent reactions
• 3 cyanopyridine derivative
• 4 Amino 3 trifluoromethyl 5 mercapto 1 2 4 triazole
• HCT cancer cell lines
• Typical hydrazone chromophore
• Phosphorus oxychloride
• Nucleophilic substitution reactions
• Chloropyrimidine derivative
• Bis chalcone
• Bis N thiocarbamoylpyrazole
• Bis pyrazolylthiazole
• Rat brain tumor cells
• 1 4 Phenylene bis chalcone
• 1 4 phenylene bis pyrimidine
• 5 fluorouracil
• High concentrations cell selectively