tailieunhanh - Synthesis and characterization of 4-((5-bromo-1H-pyrazolo [3,4-b]pyridin-3-yl)amino)-N-(substituted)benzenesulfonamide as Antibacterial, and Antioxidant Candidates

A series of novel 5-Bromo-3-iodo-1H-pyrazolo[3,4-b]pyridine linked various sulfonamide derivatives 8a-8j poly functionalized were designed and synthesized in moderate to good yield. | Synthesis and characterization of 4- 5-bromo-1H-pyrazolo 3 4-b pyridin-3-yl amino -N- substituted benzenesulfonamide as Antibacterial and Antioxidant Candidates Current Chemistry Letters 8 2019 177 186 Contents lists available at GrowingScience Current Chemistry Letters homepage Synthesis and characterization of 4- 5-bromo-1H-pyrazolo 3 4-b pyridin-3- yl amino -N- substituted benzenesulfonamide as Antibacterial and Antioxidant Candidates Hiren H. Variyaa Vikram Panchala and a Department of Chemistry Sheth M. N. Science College NGES campus Patan India CHRONICLE ABSTRACT Article history A series of novel 5-Bromo-3-iodo-1H-pyrazolo 3 4-b pyridine linked various sulfonamide Received May 8 2019 derivatives 8a-8j poly functionalized were designed and synthesized in moderate to good Received in revised form yield. A starting with iodination of 5-Bromo-1H-pyrazolo 3 4-b pyridine 5 with iodine May 12 2019 produced intermediate 5-Bromo-3-iodo-1H-pyrazolo 3 4-b pyridine 6 with the reaction of Accepted May 28 2019 various sulfonamide derivatives 7a-7j via copper catalyzed coupling reaction produced Available online targeted compounds8a-8j. The isolated compounds were accepted by spectral and elemental May 28 2019 analysis. The compounds 8a 8c 8d and 8i were excellent active against Gram-positive and Keywords gram-negative bacterial strain compare to streptomycin standard drug. All synthesized Sulfonamide 1H-pyarazolo 3 4- b pyridin compounds showed moderate to good antioxidant properties with used DPPH and Superoxide Antioxidant radical scavenging assay Compounds 8c 8g and 8i exerted significant antioxidant scavenging Anti-bacterial activity activity for the DPPH radical. Spectral studies 2019 by the authors licensee Growing Science Canada. 1. Introduction Mainly medicinal scientist has drawn the awareness to discover and rapid development of N S and O containing versatile heterocyclic entities because of their natural and synthetic .