tailieunhanh - Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media

Pioglitazone hydrochloride (PGH) is an oral anti-hyperglycemic agent used in the treatment of type-2 diabetes mellitus. Potassium permanganate was found to oxidize PGH both in acidic and basic conditions, based on which two simple and sensitive methods were developed for its determination in bulk sample and tablets, and validated. | Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media Current Chemistry Letters 7 2018 45 56 Contents lists available at GrowingScience Current Chemistry Letters homepage Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media Kanakapura Basavaiaha and Nagaraju Rajendraprasadb a Department of Chemistry University of Mysore Manasagangothri Myssuru-570 006 Karnataka India b PG Department of Chemistry JSS College of Arts Commerce amp Science B N Road Mysuru-570 025 Karnataka India CHRONICLE ABSTRACT Article history Pioglitazone hydrochloride PGH is an oral anti-hyperglycemic agent used in the treatment Received December 22 2017 of type-2 diabetes mellitus. Potassium permanganate was found to oxidize PGH both in acidic Received in revised form and basic conditions based on which two simple and sensitive methods were developed for its March 21 2018 determination in bulk sample and tablets and validated. In the first method indirect method Accepted March 25 2018 PGH was reacted with a measured excess of standard permanganate in H2SO4 medium and Available online the residual oxidant was determined by measuring its absorbance at 550 nm. The second March 25 2018 method Direct method entails treating PGH with permanganate in NaOH medium followed Keywords by the measurement of the resulting bluish-green manganite at 610 nm. Experimental variables Pioglitazone Determination affecting the reactions were studied and optimized. Under optimum conditions linear Permanganate relationships with good correlation coefficients were found between absorbance and Spectrophotometry concentration in the ranges 25 µg mL-1 Indirect method and 1-12 µg mL-1 Direct Pharmaceuticals method with respective molar absorptivity values of 104 and 104 l mol-1 cm-1. The limits of detection LOD and quantification LOQ were and Indirect method and and µg mL-1 .

• Hoá học
• Acidic and basic media
• Oral anti hyperglycemic agent
• Type 2 diabetes mellitus
• Bluish green manganite
• Intra day and inter day