tailieunhanh - Direct analysis of mAb aggregates in mammalian cell culture supernatant

Protein aggregation during monoclonal antibody (mAb) production can occur in upstream and downstream processing (DSP). Current methods to determine aggregate formation during cell culture include size exclusion chromatography (SEC) with a previous affinity chromatography step in order to remove disturbing cell culture components. | Direct analysis of mAb aggregates in mammalian cell culture supernatant

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