tailieunhanh - In search of the mRNA modification landscape in plants

Precise regulation of gene expression is indispensable for the proper functioning of organisms in both optimal and challenging conditions. The most commonly known regulative mechanisms include the modulation of transcription, translation and adjustment of the transcript, and protein half-life. | Chmielowska-Bạk et al. BMC Plant Biology 2019 19 421 https s12870-019-2033-2 REVIEW Open Access In search of the mRNA modification landscape in plants Check for updates Jagna Chmielowska-Bạk @ Magdalena Arasimowicz-Jelonek and Joanna Deckert Abstract Background Precise regulation of gene expression is indispensable for the proper functioning of organisms in both optimal and challenging conditions. The most commonly known regulative mechanisms include the modulation of transcription translation and adjustment of the transcript and protein half-life. New players have recently emerged in the arena of gene expression regulators - chemical modifications of mRNAs. Main text The latest studies show that modified ribonucleotides affect transcript splicing localization secondary structures interaction with other molecules and translation efficiency. Thus far attention has been focused mostly on the most widespread mRNA modification - adenosine methylation at the N6 position m6A . However initial reports on the formation and possible functions of other modified ribonucleotides such as cytosine methylated at the 5 position m5C 8-hydroxyguanosine 8-OHG and 8-nitroguanosine 8-NO2G have started to appear in the literature. Additionally some reports indicate that pseudouridine T is present in mRNAs and might perform important regulatory functions in eukaryotic cells. The present review summarizes current knowledge regarding the above-mentioned modified ribonucleotides m6A m5C 8-OHG 8-NO2G in transcripts across various plant species including Arabidopsis rice sunflower wheat soybean and potato. Conclusions Chemical modifications of ribonucleotides affect mRNA stability and translation efficiency. They thus constitute a newly discovered layer of gene expression regulation and have a profound effect on the development and functioning of various organisms including plants. Keywords RNA modifications Epitranscriptomics Methylation Oxidation Nitration Modified .

• Sinh học
• BMC Plant Biology
• RNA modifications
• Modified ribonucleotides
• Protein half life
• Gene expression
• Precise regulation
• Single plant genome wide association study
• Plant height
• Bulk segregant analysis
• Genome wide association studies
• Virus vector host interaction
• Plant defense
• Jasmonic acid
• Plant volatile
• Bemisia tabaci
• Terpenoid indole alkaloid
• Madagascar periwinkle
• Transcription factors
• Plant secondary metabolism
• High throughput sequencing
• Plant stress response
• Chemical library
• Pollen tube
• Growth regulator
• Modulate plant growth
• Community ecology
• Competitive exclusion
• Latitudinal gradients
• Plant–fungus interactions
• Plant–soil feedback
• Biodiversity effects
• Experimental grassland
• Herbivore induced plant volatiles
• Volatile organic compounds
• Herbivore induced plant volatiles
• Solidago altissima
• Eurosta solidaginis
• Plant physiology
• Auxin quantification
• Isotope dilution analysis
• Laser microdissection microscope
• Plant sample preparation
• Minute samples
• Linkage map
• Technical length
• Quantitative trait locus
• Pitcher plant
• DNA barcoding
• Cytochrome oxidase I
• Nepenthes genus
• Bivariate quantiles
• Conditional quantiles
• Joint estimation
• Plant growth
• Stress tolerance
• Mepiquat chloride
• Lateral root
• Plant growth regulator
• Enhances root growth
• Ammonium metabolism
• Arabidopsis thaliana
• Plant defensins
• Amino acids
• Genome wide association study
• Lint percentage
• Boll number per plant
• Boll weight per plant
• Salt stress
• Transcriptome analysis
• Gossypium hirsutum
• Catalpa bungei
• Genetic map
• RAD seq
• QTL mapping
• Leaf traits
• HN09 induced systemic resistance
• Plant immune
• Plant growth promoting rhizobacteria
• Bacillus subtilis HN09
• Plant architecture
• RNA Seq
• Internode elongation
• Plant hormone
• Physic nut
• Arabidopsis TFL1
• Mutants reveals cytokinin
• Woody plant Jatropha curcas
• Sucrose transporters
• Abiotic stress
• ABA signaling pathway
• Stomatal closure
• Tomato plant
• Pathogenesis related gene 1
• Regulatory mechanism
• Transcription factor
• RNA polymerase III
• Plant specific zinc dependent
• DNA binding proteins
• Meta transcriptomics
• Plant abiotic stress
• Plant biotic stress
• Crop physiology
• ABA hypersensitive
• Plant biological
• Including phytohormone homeostasis
• Plant development
• Photosynthetic plant life
• Plants perceive UV B
• Non plant organisms
• Guanine nucleotide exchange factors
• Chromatin immunoprecipitation
• Colletotrichum gloeosporioides
• Induced response
• Plant–pathogen interaction
• Polyphenol oxidase