tailieunhanh - Some glycosides isolated from desmodium gangeticum (L.) DC. of Viet Nam

From the methanol extract of the leaves of Desmodium gangeticum collected in Me Linh, Ha Noi, we isolated 5 compounds. In which, there are four glycosides including (6S,9R)- roseoside (1), kaempferol-3-O-rutinoside (nicotiflorin) (2), quercetin-3-O-rutinoside (rutin) (3), β-sitosterol-3-O- β-D-glucopyranoside (4), and the other is protocatechuic acid (5). Kaempferol3-O-rutinoside (2) was isolated from Desmodium gangeticum for the first time while (6S,9R)- roseoside (1) was isolated from the genus Desmodium for the first time. Their structures were determined by 1D and 2D NMR spectra. | Some glycosides isolated from desmodium gangeticum (L.) DC. of Viet Nam Vietnam Journal of Science and Technology 56 (2A) (2018 ) 99-103 SOME GLYCOSIDES ISOLATED FROM DESMODIUM GANGETICUM (L.) DC. OF VIET NAM Le Minh Ha1*, Ngo Thi Phuong 1, Le Ngoc Hung2, Vu Thi Hai Ha3, Bui Kim Anh4, Pham Quoc Long1 1 Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 2 Pharmaceutical Chemistry Lab Project, Center for Research and Technology Transfer, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 3 Hanoi University of Science, Vietnam National University, Ha Noi, 334 Nguyen Trai, Thanh Xuan, Ha Noi 4 Institute of Chemistry, VAST, 18-Hoang Quoc Viet, Nghia Do, Cau Giay, Ha Noi * Email: halm2vn@ Received: 11 March 2018; Accepted for publication: 14 May 2018 ABSTRACT From the methanol extract of the leaves of Desmodium gangeticum collected in Me Linh, Ha Noi, we isolated 5 compounds. In which, there are four glycosides including (6S,9R)- roseoside (1), kaempferol-3-O-rutinoside (nicotiflorin) (2), quercetin-3-O-rutinoside (rutin) (3), β-sitosterol-3-O- β-D-glucopyranoside (4), and the other is protocatechuic acid (5). Kaempferol- 3-O-rutinoside (2) was isolated from Desmodium gangeticum for the first time while (6S,9R)- roseoside (1) was isolated from the genus Desmodium for the first time. Their structures were determined by 1D and 2D NMR spectra. Keywords: Desmodium gangeticum, (6S,9R)-roseoside, kaempferol-3-O-rutinoside, quercetin-3- O-rutinoside, β-sitosterol-3-O-β-D-glucopyranoside, protocatechuic acid. 1. INTRODUCTION Desmodium gangeticum (L.) DC. (Fabaceae) is a slightly woody perennial herb and widely distributed in South East Asia, India and Africa. In Vietnam and other countries, D. gangeticum has been used for various purposes such as wound ulcers, snake bites, diuretic, edema, asthma, stomatitis, arthritis, eczema, hair loss, neurological disorders, .