tailieunhanh - Corticosteroids: Use or misuse in veterinary medicine

Due to broad range of effects, corticosteroids are frequently used in veterinary practice. Wide ranges of biological effects are mediated via different dose and potency of different glucocorticoids. Intensive short-term glucocorticoid use can decrease the morbidity and mortality of potentially fatal conditions but in long run their use can lead to immunosuppression, duodenal ulceration, pancreatitis, adrenal atrophy, hyperadrenocorticism, glucose intolerance and many more diseases. Multitude of adverse effects distinct from pharmacologic or physiologic responses has also been associated with corticosteroid use. The dose should be tapered and changed to alternate-day therapy as soon as possible, but caution should be taken not to allow recurrence of disease. The underlying disease must also be directly addressed as corticosteroids most often only suppress symptoms without treating the disease. | EXCELLENT PUBLISHERS International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 8 Number 08 2019 Journal homepage http Review Article https Corticosteroids Use or Misuse in Veterinary Medicine Asmita Narang and Gurpreet Singh Preet Department of Veterinary Medicine Guru Angad Dev Veterinary and Animal Sciences University Ludhiana India Corresponding author ABSTRACT Keywords Corticosteroids Glucocorticoids Antiinflamatory Immunosuppression Article Info Accepted 10 July 2019 Available Online 10 August 2019 Due to broad range of effects corticosteroids are frequently used in veterinary practice. Wide ranges of biological effects are mediated via different dose and potency of different glucocorticoids. Intensive short-term glucocorticoid use can decrease the morbidity and mortality of potentially fatal conditions but in long run their use can lead to immunosuppression duodenal ulceration pancreatitis adrenal atrophy hyperadrenocorticism glucose intolerance and many more diseases. Multitude of adverse effects distinct from pharmacologic or physiologic responses has also been associated with corticosteroid use. The dose should be tapered and changed to alternate-day therapy as soon as possible but caution should be taken not to allow recurrence of disease. The underlying disease must also be directly addressed as corticosteroids most often only suppress symptoms without treating the disease. Introduction The adrenal cortex synthesizes two classes of steroids the corticosteroids glucocorticoids and mineralocorticoids have 21 carbon atoms and the androgens which have 19. The actions of corticosteroids historically were described as glucocorticoid carbohydrate metabolism-regulating and mineralocorticoid electrolyte balance-regulating reflecting their preferential activities Goodman 1996 . The glucocorticoids such as cortisol and related synthetics prednisone and dexamethasone and numerous .