tailieunhanh - Probiotics for infantile colic: A systematic review

Infantile colic is a common paediatric condition which causes significant parental distress. Increased intestinal coliform colonization in addition to alteration in Lactobacillus abundance and distribution may play an important role in its pathogenesis. | Anabrees et al. BMC Pediatrics 2013 13 186 http 1471-2431 13 186 BMC Pediatrics RESEARCH ARTICLE Open Access Probiotics for infantile colic a systematic review Jasim Anabrees1 Flavia Indrio2 Bosco Paes3 and Khalid AlFaleh4 Abstract Background Infantile colic is a common paediatric condition which causes significant parental distress. Increased intestinal coliform colonization in addition to alteration in Lactobacillus abundance and distribution may play an important role in its pathogenesis. The objectives of this systematic review are to evaluate the efficacy of probiotic supplementation in the reduction of crying time and successful treatment of infantile colic. Methods Literature searches were conducted of MEDLINE EMBASE and the Cochrane Central Register of Controlled Trials. Only randomized controlled trials enrolling term healthy infants with colic were included. A meta-analysis of included trials was performed utilizing the Cochrane Collaboration methodology. Results Three trials that enrolled 220 breastfed infants met inclusion criteria of which 209 infants were available for analysis. Two of the studies were assessed as good quality. Lactobacillus reuteri strains-American Type Culture Collection Strain 55730 and DSM 17 938 was the only species utilized in the therapeutic intervention. Two of the trials were industry funded. Probiotic supplementation compared to simethicone or placebo significantly and progressively shortened crying times to 7 days reaching a plateau at three weeks post initiation of therapy mean difference minutes 95 CI . Similarly probiotics compared to placebo significantly increased the treatment success of infantile colic with a relative risk RR of 95 CI and a number needed to treat of 2. Conclusions Although L. reuteri may be effective as a treatment strategy for crying in exclusively breastfed infants with colic the evidence supporting probiotic use for the treatment of infant