tailieunhanh - Pulmonary manifestations in HIV patients
Pulmonary system is the most commonly involved system in people living with HIV as lungs are continuously exposed to the infection as they are rich in macrophages, dendritic cells, lymphocytes etc. In PLHIV immunity is suppressed, hence lungs are prone for infection and non infectious pulmonary diseases. According to autopsy findings, in HIV lung was affected almost upto 100% in the period of epidemic to 70% in the HAART era. Pneumonia is most common pulmonary manifestation followed by pulmonary tuberculosis and PCP. Other manifestations are infections like mycobacterium avium complex, fungal infection, nonspecific interstitial pneumonitis, Kaposi sarcoma, lymphoma. Encapsulated organisms like streptococci, H. influenzae are responsible for most cases of pneumonia. PCP is the hallmark of AIDS. It is most common with CD4 count18 yr with pulmonary symptoms were included in the study where as PLHIV with URTI were excluded. A valid written informed consent was taken. Detailed clinical history taking and examination was done. They were subjected to various investigations like CBC, RFT, LFT, CHEST XRAY, CD4 COUNT, SPUTUM ANALYSIS and other investigations like pleural fluid analysis ,CT thorax if needed. Data is statistically analysed. Out of the 36 patients studied 26 were males, 10 female. Majority of them belonged to the group of age 30-50 yr. 24 had CD4 count below 200/µl, 6 had CD4 count in the range of 200-500/µl, where as 6 had >500/µl. Most of them were on TLE regimen. 16 had pulmonary Koch,12 had pneumonia and synpneumonic effusion, 4 had PCP, 2 had bronchiectasis,2 had bronchitis. All PCP patients had cd4 | EXCELLENT PUBLISHERS International Journal of Current Microbiology and Applied Sciences ISSN 2319-7706 Volume 8 Number 07 2019 Journal homepage http Original Research Article https Pulmonary Manifestations in HIV Patients Arati Kalakutakar1 H. Suresh2 and Sumant Balagandi1 1 Department of Microbiology 2Department of Cardiology KIMS Hubli India Corresponding author ABSTRACT Keywords Pulmonary Infection HIV Article Info Accepted 07 JUne 2019 Available Online 10 July 2019 Pulmonary system is the most commonly involved system in people living with HIV as lungs are continuously exposed to the infection as they are rich in macrophages dendritic cells lymphocytes etc. In PLHIV immunity is suppressed hence lungs are prone for infection and non infectious pulmonary diseases. According to autopsy findings in HIV lung was affected almost upto 100 in the period of epidemic to 70 in the HAART era. Pneumonia is most common pulmonary manifestation followed by pulmonary tuberculosis and PCP. Other manifestations are infections like mycobacterium avium complex fungal infection nonspecific interstitial pneumonitis Kaposi sarcoma lymphoma. Encapsulated organisms like streptococci H. influenzae are responsible for most cases of pneumonia. PCP is the hallmark of AIDS. It is most common with CD4 count 200 pl. About 1 3rd of AIDS related deaths are because of tuberculosis. About 60-80 of HIV patients infected with TB have pulmonary involvement. The main aim of this study is pulmonary involvement in people living with HIV and also to study the co-relation between CD4 count and pulmonary disease in HIV. This is an observational study conducted at KIMS Hubli. Patients of HIV aged 18 yr with pulmonary symptoms were included in the study where as PLHIV with URTI were excluded. A valid written informed consent was taken. Detailed clinical history taking and examination was done. They were subjected to various investigations like CBC RfT LFT .
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