tailieunhanh - Disposition kinetics of Moxifloxacin in calves pretreated with cow urine distillate

Bio-enhancers such as piperine, curcumine, ginger and cow urine distillate are being seen as important adjuvant drugs to combat antimicrobial resistance and to increase efficiency of antimicrobial agents. Cow urine distillate is one of the important bio-enhancer easily available with farmer. The disposition kinetics was aimed to assess the pharmacokinetic alteration in profile of moxifloxacin, a third generation fluoroquinolone anti-microbial agent. Moxifloxacin was administered at the dose rate of 5 body weight by intramuscular route in calves (n=5) pretreated with cow urine distillate at the dose of 20 ml per day per animal orally for 7 days. The plasma concentration–time profile of moxifloxacin following intramuscular administration in the pretreated calves was best described by one–compartment open model. The absorption half-life (t½ka), elimination half-life (t½β), area under plasma drug concentration-time curve (AUC), area under first moment curve (AUMC), apparent volume of distribution (Vdarea), total body clearance (ClB) and bioavailability (F) of moxifloxacin were ± h, ± h, ± .h, ± .h2 , ± , ± .h-1 and ± % respectively. Cow urine distillate administration at the selected dose rate did not significantly alter the pharmacokinetic behavior of moxifloxacin administered intramuscularly in calves. | Disposition kinetics of Moxifloxacin in calves pretreated with cow urine distillate