tailieunhanh - Glactomannan index as a rapid diagnostic tool for invasive pulmonary Aspergillosis in patients with chronic lung diseases

Invasive aspergillosis has increased considerably in recent years; this serious infection was primarily described in severely immunocompromised patients and patients with moderate levels of immune suppression. We conducted this study on 85 patients admitted to the chest department and chest ICU with severe exacerbations of chronic lung diseases in the period from April 2018 to April 2019. We collected tracheal aspirates BAL fluid and blood samples for isolation of Aspergillus spp. by convectional culture and assay of galactomannan level in these samples using ELISA. Aspergillus spp. was isolated from () of tracheobroncheal aspirate samples, (11%) BAL samples and () blood samples. Aspergillus fumigatus represented (70%) of isolates while Aspergillus niger represented (25%). Galactomannan antigen was positively detected in () of serum samples, (22%) of tracheobronchial aspirates, and in () bronchoalveoalar lavage fluid samples. The sensitivity (52%) and specificity (48%) of culture were much lower than the sensitivity and specificity of galactomannan detection (92%) and (85%) respectively. proven IA patient category represented (), while Probable IA represented (), and possible IA represented (). invasive aspergillosis could be a cause of exacerbation in patients with chronic chest diseases and a cause of their unresponsiveness to relevant treatment. Galactomannan antigen detection is a rapid sensitive diagnostic test of IA in those patients that helps the clinicians to rapidly diagnose IA and start antifungal therapy. | Glactomannan index as a rapid diagnostic tool for invasive pulmonary Aspergillosis in patients with chronic lung diseases

• Y khoa - Dược
• Invasive aspergillosis
• Galactomannan antigen
• Invasive fungal infections
• Chronic lung diseases
• Rapid diagnostic tool
• BMC Pulmonary Medicine
• Pulmonary aspergillosis
• Non agranulocytic patients
• Serum Aspergillus IgG
• Invasive pulmonary aspergillosis
• Interleukin 8
• Aspergillus fumigatus
• Chitinase 3 like 1
• Bronchoalveolar lavage fluid
• Mammalian target of rapamycin
• CD8+effect memory T cells
• Invasive Pulmonary Aspergillosis
• IFN γ
• IL 12 treatment
• Influenza A
• Risk factor
• Clinical symptoms
• CT dynamic monitoring
• Aggressive pulmonary aspergillosis
• Chronic respiratory diseases
• Nonspecific radiological
• Mycological findings
• BMC Pharmacology and Toxicology
• Case report
• Therapeutic drug monitoring
• Aspergillus terreus
• Cost effectiveness
• Decision analytic model
• Invasive fungal disease
• Drug related adverse events
• báo cáo khoa học
• báo cáo y học
• công trình nghiên cứu về y học
• tài liệu về y học
• cách trình bày báo cáo
• trình bày báo cáo
• tài liệu báo cáo khoa học
• kiến thức y học
• nghiên cứu y học
• BMC Cancer
• Opportunistic infection
• Concurrent infection
• Concurrent lymphoma
• Tissue biopsy
• B cell lymphoma
• Fungal infection
• Chronic obstructive pulmonary disease
• Aspergillus sensitisation