tailieunhanh - Disseminated cutaneous histoplasmosis in a 30-Year-Old Male HIV-Positive patient: A rare case report

Histoplasmosis is a systemic mycotic infection caused by Histoplasma capsulatum, a dimorphic fungus. Although histoplasmosis can occur in immunocompetent persons, but immunocompromised individuals, such as people with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS), are at high risk of developing disseminated disease. In AIDS patients, mortality may approach 50%, due to disseminated histoplasmosis, especially in those with severe manifestations. We present a case of disseminated histoplasmosis in a 30-year-old, HIV-positive male patient on antiretroviral treatment, who presented to the Skin outpatient clinic with multiple papulonodular lesions on the face, neck, trunk and ulcers in oral cavity. General complaints included fever, malaise and weight loss, along with hepatosplenomegaly on examination. Investigations revealed pancytopenia, altered liver function and renal dysfunction. CD4 cell count was 72 cells/µl. The patient was started on Amphotericin B for 2 weeks as induction therapy followed by oral itraconazole as maintenance therapy. Histoplasmosis is rarely reported from India, which may be on account of its varied clinical presentation and lack of awareness among dermatologists, hence disseminated histoplasmosis should be considered as a differential diagnosis in an immunocompromised patient presenting with cutaneous lesions, as it is necessary for the early diagnosis and proper management of the patient. | Disseminated cutaneous histoplasmosis in a 30-Year-Old Male HIV-Positive patient: A rare case report