tailieunhanh - Neurological effects of bisphenol a and its analogues

The endocrine disrupting chemical bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. The use of BPA-containing products in daily life makes exposure ubiquitous, and the potential human health risks of this chemical are a major public health concern. | Int. J. Med. Sci. 2015 Vol. 12 926 IVYSPRING ĩvt ơ-rnrt irmrtí clrni t n lí ei-fCMo Tir lT Qriữvtrơc INTERNATIONAL PUBLISHER international journal Oj jVLeaicaiSciences 2015 12 12 926-936. doi Review Neurological Effects of Bisphenol A and its Analogues Hidekuni Inadera Department of Public Health Faculty of Medicine University of Toyama 2630 Sugitani Toyama 930-0194 Japan El Corresponding author Hidekuni Inadera MD PhD Department of Public Health Faculty of Medicine University of Toyama 2630 Sugitani Toyama 930-0194 Japan. Email inadera@ Tel 81-76-434-7275 Fax 81-76-434-5023 2015 Ivyspring International Publisher. Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. See http terms for terms and conditions. Received Accepted Published Abstract The endocrine disrupting chemical bisphenol A BPA is widely used in the production of polycarbonate plastics and epoxy resins. The use of BPA-containing products in daily life makes exposure ubiquitous and the potential human health risks of this chemical are a major public health concern. Although numerous in vitro and in vivo studies have been published on the effects of BPA on biological systems there is controversy as to whether ordinary levels of exposure can have adverse effects in humans. However the increasing incidence of developmental disorders is of concern and accumulating evidence indicates that BPA has detrimental effects on neurological development. Other bisphenol analogues used as substitutes for BPA are also suspected of having a broad range of biological actions. The objective of this review is to summarize our current understanding of the neurobiological effects of BPA and its analogues and to discuss preventive strategies from a public health perspective. Key words Bisphenol A Epigenetics Neurodevelopment Introduction Bisphenols BPs form a large family

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