tailieunhanh - Role and new insights of pirfenidone in fibrotic diseases

Pirfenidone (PFD) is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-β1, TNF-α, PDGF and COL1A1 expression, which is highly related to prevent or remove excessive deposition of scar tissue in several organs. | Int. J. Med. Sci. 2015 Vol. 12 840 IVYSPRING ĩtttonmtìnníií n-C OM ơrdrnf ĩriữnrữc INTERNATIONAL PUBLISHER international journal Oj jVLeaicai Sciences 2015 12 11 840-847. doi Review Role and New Insights of Pirfenidone in Fibrotic Diseases David Alejandro Lopez-de la Mora1 Cibeles Sanchez-Roque1 Margarita Montoya-Buelna1 Sergio Sanchez-Enriquez1 Silvia Lucano-Landeros1 Jose Macias-Barragan1 2 Juan Armendariz-Borunda1 E 1. Institute for Molecular Biology and Gene Therapy Department of Molecular Biology and Genomics University of Guadalajara Sierra Mojada St. 950 Guadalajara 44280 Mexico. 2. Departamento de Ciencias de la Salud CUValles University of Guadalajara Guadalajara - Ameca km. Ameca 46600 Mexico. El Corresponding author armdbo@ 2015 Ivyspring International Publisher. Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. See http terms for terms and conditions. Received Accepted Published Abstract Pirfenidone PFD is a non-peptide synthetic molecule issued as a broad-spectrum anti-fibrotic drug with the ability to decrease TGF-p1 TNF-a PDGF and COL1A1 expression which is highly related to prevent or remove excessive deposition of scar tissue in several organs. Basic and clinical evidence suggests that PFD may safely slow or inhibit the progressive fibrosis swelling after tissue injuries. Furthermore a number of evidence suggests that this molecule will have positive effects in the treatment of other inflammatory diseases. This review contains current research in which PFD has been used as the treatment of several diseases and focus mainly in the outcomes related to improve inflammation and fibrogenesis. Therefore the main goal of this review is to focus on the novel findings of PFD efficacy rather than deepen in the chemical aspects of the molecule. Key words Pirfenidone fibrosis inflammation .