tailieunhanh - A report of two children with GorhamStout disease

Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis (variant of idiopathic nonhereditary osteolytic disease) with a slow progression, which is self-limiting for some years. | Tena-Sanabria et al. BMC Pediatrics 2019 19 206 https s12887-019-1561-0 CASE REPORT A report of two children with Gorham-Stout disease Open Access Check for updates Mario Edgar Tena-Sanabria1 Larisa Yarindy Jesus-Mejenes1 Gabriela Fuentes-Herrera1 Felix Alejandro Álvarez-Martínez1 Nora Patricia Victorio-García2 and Juan Carlos Nunez-Enriquez2 Abstract Background Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis variant of idiopathic nonhereditary osteolytic disease with a slow progression which is self-limiting for some years. It is characterized by recurrent vascular tumors with disruption of the anatomical architecture and intraosseous proliferation of vascular channels that leads to the destruction and resorption of the bone matrix. The aim of this study is to present the clinical features of this disease as well as the importance of prompt diagnosis and treatment with a review of the reported cases. Case reports We describe two cases of Gorham-Stout disease between 2013 and 2017 with surgical interventions follow-up and results. Case one involves an 11-year-old male with involvement of the left iliac bone with adequate evolution after a surgical procedure with a lyophilized cadaveric tricortical bone allograft. Case two involves a 6-year-old male with cervical spine C1-C3 repercussion in the protocol for surgical treatment he presented with signs of spinal cord compression and died. Conclusion Diagnosis of Gorham-Stout disease is made by exclusion and its clinical presentation varies widely from spontaneous remission to a fatal outcome. Keywords Gorham-stout disease Idiopathic osteolysis Children Pediatric orthopedics Background Gorham-Stout disease is a rare condition characterized by unifocal and massive type IV osteolysis a type of idiopathic nonhereditary osteolytic disease with a slow progression which is self-limiting in some years. It is characterized by recurrent vascular tumors with .

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