tailieunhanh - Nghiên cứu bào chế hệ phân tán rắn của rutin bằng phương pháp phun sấy

Rutin có độ hòa tan kém do đó sinh khả dụng đường uống thấp. Mục đích của nghiên cứu này nhằm tăng độ tan và sinh khả dụng của rutin bằng cách tạo hệ phân tán rắn của rutin. | Nghiên cứu bào chế hệ phân tán rắn của rutin bằng phương pháp phun sấy VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 35, No. 2 (2019) 27-36 Original Article Preparation of solid dispersion of rutin by spay drying Nguyen Van Khanh1,*, Ta Thi Thu1, Hoang Anh Tuan2 1 VNU School of Medicine and Pharmacy, 144 Xuan Thuy, Cau Giay, Hanoi, Vietnam 2 Military Hospital 108, 1 Tran Hung Dao, Hai Ba Trung, Hanoi, Vietnam Received 01 November 2019 Revised 18 November 2019; Accepted 29 November 2019 Abstract: The poor solubility of rutin leads to poor bioavailability. The present study is aimed to increase the solubility and bioavailability of rutin using solid dispersion technique. The solid dispersions of rutin were prepared by spray-dried method using β-CD, HPMC E6, HPMC E15, PVP K30, SLS, poloxamer 188 and Tween 80 as carriers. The interaction of rutin with the carriers was evaluated by using methods such as dissolved measurement, Fourier-transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The optimization of formulation was carried out by using Central Composite Face design. Independent variables include PVP K30/rutin ratio, Tween 80/rutin ratio, inlet air temperature, and feed flow rate. Dependent variables are the dissolution and product yield. The optimized preparation conditions for rutin solid dispersions were obtained as PVP K30: rutin at a ratio of , Tween 80: rutin at a ratio of , inlet temperature of , flow rate of ml per hour. The results of this study indicate that the solid dispersion of rutin increases significantly the dissolution of rutin in comparison with rutin. The results of the DSC and XRD studies prove the state transition of rutin from crystalline to amorphous. Keywords: Rutin, solid dispersion, spray drying, PVP K30, dissolution. _ Corresponding author. Email .