tailieunhanh - Đa hình đơn nucleotide APOC3-rs2854116 liên quan đến rối loạn cholesterol tổng số ở trẻ em tiểu học tại Hà Nội

Gen Apolipoprotein C3 (APOC3) giữ vai trò quan trọng trong việc điều chỉnh nồng độ lipid của cơ thể. Nghiên cứu này được tiến hành nhằm đánh giá mối liên quan của đa hình APOC3- rs2854116 với rối loạn lipid máu (RLLM) ở trẻ tiểu học tại Hà Nội. | Đa hình đơn nucleotide APOC3-rs2854116 liên quan đến rối loạn cholesterol tổng số ở trẻ em tiểu học tại Hà Nội VNU Journal of Science: Medical and Pharmaceutical Sciences, Vol. 35, No. 2 (2019) 78-86 Original Article APOC3-rs2854116 polymorphism related to hypercholesterolemia in primary school children in Hanoi Nguyen Thi Hong Hanh1, Tran Quang Binh2,* 1 Hanoi National University of Education, 136 Xuan Thuy, Cau Giay, Hanoi, Vietnam 2 National Institute of Nutrition, 48B Tang Bat Ho, Hanoi, Vietnam Received 13 December 2018 Revised 13 May 2019; Accepted 5 July 2019 Abtract: Apolipoprotein C3 (APOC3) plays an important role in regulating lipid levels. This study aimed to assess whether the polymorphism APOC3-rs2854116 is associated with lipid profiles in primary school children in Hanoi. A case-control study was designed including 161 cases with dyslipidemia and 406 controls without dyslipidemia. Genotype for APOC3-rs2854116 polymorphism was determined by the polymerase chain reaction and restriction fragment length polymorphism method (PCR-RFLP). The results showed that there were differences in the effect of APOC3-rs2854116 polymorphism to lipid profiles among children with dyslipidemia. In comparison with A/G and A/A carriers, the G/G carriers had the higher concentration of serum TC, TG, and LDL-C (P < ). APOC3-rs2854116 polymorphism was related to hypercholesterolemia in children with the most appropriate genetic model being additive model. Increasing each of the G alleles increased the risk of hypercholesterolemia by times (P = ) after adjustment for age and sex. This relationship was almost unchanged after adjustment for obesity-related traits. The study suggested that the APOC3-rs2854116 polymorphism significantly associated with hypercholesterolemia in primary school children in Hanoi independent of obesity-related traits. Key words: APOC3, rs2854116, .