tailieunhanh - Study on medicinal plants of Kashmir valley for anti-proliferative, anti-invasive activities against prostate cancer

Treatment of castration-resistant prostate cancer (CRPC) patients with androgen deprivation therapy puts prostate cancer in remission while treatment with already available drugs in market including abirater one help in controlling advanced prostate cancers for sometime though fail to respond, evolve resistance mechanisms, and undergo genetic deregulations later on with poor patient survival rate and no cure. Also, if present trends of increasing life expectancy continue, given the current age-specific incidence, mortality rates of prostate cancer, this disease will become a far greater health problem worldwide in future. For this reason, addressing the curative treatment strategies for prostate cancer was the focal theme of our investigation. Our emphasis was on the extracts from medicinal plants of Kashmir Valley, which we collected from different floristically rich regions of Valley including Leh-Ladakh, Gurez, Dachigam National Sanctuary, Jawahar Lal Nehru Memorial Botanical Garden, Medicinal Plants Emporium Srinagar, Faculty of Forestry, SKUAST-K, Kangan and local nurseries in Srinagar area. In this study, we screened library of 372 extracts from collected medicinal plants (52) for their antiproliferative and anti-invasive efficacy through colony forming units and wound healing assays, which led to the identification of leaf extract of Podophyllum hexandrum as inhibitor molecule. | Study on medicinal plants of Kashmir valley for anti-proliferative, anti-invasive activities against prostate cancer

• Y khoa - Dược
• Kashmir Himalayas
• Medicinal plants
• Prostate cancer
• Colony forming unit assay
• Wound healing assay
• Insect pollinator diversity
• Major traditional leafy vegetables kale
• Vegetables kale (Brassica oleracea var
• acephala)
• Knol Khol (Brassica oleracea var
• gongylodes)
• Biodiversity index
• Species Richness
• Zabarvan forest
• Ectomycorrhizal diversity
• Bacillus cereus
• Colletotrichum capsici
• Zinc solubilizing bacteria
• Isolation and characterization
• Colletotricum capsici
• Clostridium perfringens
• 16S rRNA
• Multiplex PCR
• Clostridium perfringens type D isolated
• Molecular characterisation
• Picea smithiana
• Seed germination of spruce
• Seeds under temperate conditions
• Different pre sowing treatments
• Growth of seeds Picea smithiana
• Elaeagnus umbellata
• SDS PAGE
• Biochemical analysis
• Evolutionary pattern
• Azad Kashmir
• BMC Pharmacology and Toxicology
• Cell migration
• In vitro wound healing assay
• Microtubule binding agents
• Benzophenanthridine alkaloids
• Caspase 3
• Real time polymerase chain reaction
• Wound healing
• Migration assay
• Fetal bovine serum