tailieunhanh - Patho-morphological and genotoxic changes in induced Aflatoxicosis in white Pekin ducks (Anas platyrhynchos domesticus)

The present study attempts to analyze gross and microscopic changes in tissues and genotoxic assessment in bone marrow cells in ducks induced with aflatoxin study was carried out in 120 nos. of white Pekin ducklings. Ducklings were reared under standard managemental system with ad libitum feed and water etc. for a period of 8 B1 added to the feed with different proportion at the dose rate of 6ppb, 12ppb, 24 ppb, &48ppb through premix which were fed to the ducklings of Group 2, 3, 4, 5 respectively, after 3 days with Group 1 as control group. There was a significantly higher chromosomal aberration and micronuclei and lower polychromatic erythrocytes (PCE) in ducks fed with 48 ppb. Grossly liver was enlarged, pale, soft and friable with marked congestion in 48 ppbAFB1. Marked enlargement with reticulation of kidney was evident in group fed with 48 ppb. Bursa was edematous and bursal folds were mildly congested where asthymus was enlarged and pale with petechial. Intestinal wall was slightly thickened with catarrhal exudates and some cases reddish tinged catarrhal exudates in the lumen. Microscopically, at 48 ppb, liver revealed vacuolar degeneration of hepatocytes and mild sinusoidal congestion and focal necrotic area. There was tubular degeneration along with interstitial congestion and desquamated tubular lining epithelial cells in kidney. Lymphoid depletion was evident in bursa of Fabricius and thymus. Toxicopathological effect was pronounced at 48 ppb of aflatoxin B1. | Patho-morphological and genotoxic changes in induced Aflatoxicosis in white Pekin ducks (Anas platyrhynchos domesticus)