tailieunhanh - A comparative study of screening of hepatitis B by two different immunochromatographic methods among patients attending a Tertiary care hospital

Hepatitis B is one of the major Global health problems affecting both developing and developed countries. Hepatitis B is caused by Hepatitis B virus which spreads parentally through blood and sexual contact. There are many markers which gives information regarding stages of hepatitis B viral infection. The HBsAg is used for detection and screening of HBV infection. Aim: The study was carried to compare different parameters viz. sensitivity, specificity, positive and negative predictive values of two immunochromatographic Rapid tests with ELISA for HBsAg. Study Design. The study was conducted in Department of Microbiology at SKIMS-MC Hospital for a period of one year. Result: Out of total of 6701 blood samples screened, 19 were positive by ELISA, 17 were positive by Test A (HepaTM Card) and 16 were positive by Test B (Alere Trueline). The sensitivity, specificity, negative and positive predictive value of test A were , 100%, and 100%. The sensitivity, specificity, negative and positive predictive value of test B were , 100%, and 100% respectively against ELISA. The Rapid tests (ICT) are not comparable to ELISA in terms of sensitivity but can be used for screening of Hepatitis B in developing countries where resources are limited as rapid tests are cost effective and easy to perform. | A comparative study of screening of hepatitis B by two different immunochromatographic methods among patients attending a Tertiary care hospital