tailieunhanh - Vasorelaxant effect of heteratisine and 6–O–Benzoyl Heteratisine on functional activity of rat aorta smooth muscle cells
The effect of geteratisin (3–200 micromol/L) and 6–O–benzoylgeteratisin (10–250 micromol/L) on the contractile activity of the rat aorta smooth muscle cells (SMC) was studied. Isometric tension forces were recorded using a force transducer FT–03 (Grass Instrument Co., USA). In the experiments it was revealed that vasorelaxant effect of heteratisine is mainly associated with the blockade of Ca2+L–channel, receptor–operated Ca2+ –channels (ROCC), and store–operated Ca2+–channels (SOCC). Vasorelaxant effect of 6–O–benzoyl heteratisine, which differs from heteratisine with the location of the benzoyl group in C(6)–position, is associated not only with the Ca2+L–channel blockade and SOCC/ROCC and the activation of the NO/cGC/cGMP/PKG cascade reaction. | Vasorelaxant effect of heteratisine and 6–O–Benzoyl Heteratisine on functional activity of rat aorta smooth muscle cells
đang nạp các trang xem trước