tailieunhanh - Hepato-protective effects of crude phenol and petroleum spirit root extracts of Calotropis Procera (Sodom of Apple) on CCL4 Induced Hepatotoxicity in Albino Rats

The efficiency of current synthetic agents in treating chronic liver disease is not satisfactory and they have undesirable side effects. The effects of crude phenol root extracts of Calotropis procera, petroleum spirit root extracts of Calotropis procera (PRECP, PSRECP) and livolin on liver function indices of ccl4 induced hepatotoxicity rats model was evaluated. Fifty (50) albino rats were grouped into Five (I, II, III, IV and V) of 10 rats each, 120mg/kg body weight ccl4 diluted with olive oil in the ratio 1:1 was administered to rats in groups II, III, IV and V intramuscularly followed by oral administration of 10mg/kg livolin, 10mg/kg, crude phenol and petroleum spirit root extracts of C. Procera to group III, IV and V respectively. Groups I and II serves as positive and test control respectively. Analysis of variance (ANOVA) for multiple comparison test were used to compare the indices of the liver and kidney functions for the test and control group at 10 days interval for 20 days. | Hepato-protective effects of crude phenol and petroleum spirit root extracts of Calotropis Procera (Sodom of Apple) on CCL4 Induced Hepatotoxicity in Albino Rats